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Who this guide applies to
This guide covers the shared practical issues that can arise with GLP-1 and related weight-management medicines, including semaglutide (Wegovy), liraglutide (Saxenda) and the dual GIP/GLP-1 medicine tirzepatide (Mounjaro).
These medicines are not identical. Doses, devices, missed-dose rules, storage instructions, interactions and some side effects differ. Follow the instructions for your own prescribed medicine and check its patient leaflet when the advice needs to be product-specific.
Do not take another dose and seek urgent medical help
The key warning sign is severe, persistent pain in the stomach area. The pain may spread through to your back and may happen with or without nausea and vomiting.
Do not take another dose and do not wait for your next planned review. Seek urgent medical assessment straight away.
Quick answer
Pancreatitis means inflammation of the pancreas. It is an uncommon but serious possible side effect of GLP-1 and related medicines. Common mild nausea or a brief stomach upset is not the same as pancreatitis, but severe pain that does not go away needs urgent assessment.
What should I tell the clinician?
- The exact medicine you are taking, its dose and brand name.
- When you took your last dose and the dose strength.
- Where the pain is, whether it travels to your back and when it began.
- Whether you are vomiting, have a fever or feel very unwell.
- Whether you have ever had pancreatitis or gallstones.
The one thing to remember
Severe, persistent stomach pain means do not take another dose and seek urgent medical help. This website cannot tell whether your pain is pancreatitis.
Read the fuller guide
For a balanced overview of serious and common risks, read Weight-loss medicines: benefits and risks.
Official sources
MHRA: strengthened pancreatitis warnings for GLP-1 and dual GLP-1/GIP medicines
First published July 2026. Scope and content reviewed 30 October 2026 against current MHRA, NHS and NICE guidance. Review earlier if product information changes.
Prepared for the Pathfields Healthy Living Portal.